Water → HCID 64393182, compound

HRID 1907872Notes

Reaction equation

HRID 1907872 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=O)[N:5]=[CH:4][CH:3]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:33][C:34]1([CH3:41])[CH2:39][CH2:38][CH:37]([NH2:40])[CH2:36][CH2:35]1.O>CN(C=O)C>[CH3:33][C:34]1([CH3:41])[CH2:39][CH2:38][CH:37]([NH:40][C:8]([C:6]2[CH:7]=[C:2]([NH2:1])[CH:3]=[CH:4][N:5]=2)=[O:10])[CH2:36][CH2:35]1

Participants

6

Reactant 4

HCID 962WaterHCID 4210544,4-Dimethylcyclohexan-1-amineHCID 20501324-Aminopicolinic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Product 1

HCID 64393182HCID 64393182, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of 4-amino-pyridine-6-carboxylic acid (250 mg, 1.81 mmol) with TBTU (600 mg, 1.87 mmol) and TEA (1 mL, 7.2 mmol) in 4 mL DMF was added 4,4-dimethyl-cyclohexylamine (300 mg, 1.83 mmol) and the mixture stirred at ambient temperature for 1 h. Then the mixture was poured into water at 0° C. and stirred for 5 min. The precipitate was filtered off, washed with water and dried at 55° C.

Workup

  1. stirringstirred for 5 min
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried at 55° C.

Sources & evidence

ORD record
ord-dd89f9d5e2044355b2de87e8805bb880
Source dataset
uspto-grants-2013_12
Patent number
US08598190B2

Reaction notes

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