HCID 66997917, compound → HCID 66997919, compound

HRID 1907873Notes

Reaction equation

HRID 1907873 reaction equation
[CH3:1][C:2]1([CH3:21])[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([N+:18]([O-])=O)=[CH:13][N:12]=2)=[O:10])[CH2:4][CH2:3]1>CO.[Ni]>[CH3:1][C:2]1([CH3:21])[CH2:3][CH2:4][CH:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[CH:13][N:12]=2)=[O:10])[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 66997917HCID 66997917, compound

Product 1

HCID 66997919HCID 66997919, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

The product obtained in 83c (100 mg, 0.34 mmol) in 10 mL methanol was mixed with Raney nickel (25 mg) and hydrogenated at 3.4 bar for 2.5 h in a Parr apparatus. The mixture was filtered and the filtrate concentrated i. vac.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated i

Sources & evidence

ORD record
ord-36a3cf9162934be5910aebb7bc371a70
Source dataset
uspto-grants-2013_12
Patent number
US08598190B2

Reaction notes

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