HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 2-Bromo-5-fluoropyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Bromo-5-fluoropyridine | HCID 2783171 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Bromo-5-fluoropyridine 1-oxide | HCID 55251048 | — |
Reaction Steps
2-Bromo-5-fluoropyridine (15 g, 85.6 mmol), trifluoroacetic acid (70 mL, 908 mmol) and hydrogen peroxide (35% in water) (9 mL, 105 mmol) were stirred overnight at 70° C. The mixture was poured into water and extracted with dichloromethane. The organic layers were washed with NaHCO3 (aq), dried over MgSO4 and the solvent was removed i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598190B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bbe4fada2d864a138ac62051dc94f10b |
| Source note | uspto-grants-2013_12 |