反应详情

2-Bromo-5-fluoropyridine (15 g, 85.6 mmol), trifluoroacetic acid (70 mL, 908 mmol) and hydrogen peroxide (35% in water) (9 mL, 105 mmol) were stirred overnight at 70° C. The mixture was poured into water and extracted with dichloromethane. The organic layers were washed with NaHCO3 (aq), dried over MgSO4 and the solvent was removed i.vac.

1. extractionextracted with dichloromethane
2. washThe organic layers were washed with NaHCO3 (aq)
3. dry with materialdried over MgSO4
4. customthe solvent was removed i.vac