HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-5-(methylamino)-4-nitropyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-Bromo-5-fluoro-4-nitropyridine 1-oxide | HCID 70700804 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Bromo-5-(methylamino)-4-nitropyridine 1-oxide | HCID 86659129 | — |
Reaction Steps
2-Bromo-5-fluoro-4-nitropyridine 1-oxide (11.2 g, 47 mmol) and 2 N methylamine (solution in THF) (48 mL, 96 mmol) in 150 mL THF was stirred for 5 min at ambient temperature. Water was poured into the mixture and THF was removed i.vac. The solid was filtered, washed with water and dried at 50° C. i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598190B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-49b067ffd92e433f89895b16aa950197 |
| Source note | uspto-grants-2013_12 |