Water → 2-Bromo-5-(methylamino)-4-nitropyridine 1-oxide

HRID 1907876Notes

Reaction equation

HRID 1907876 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5](F)=[CH:4][N+:3]=1[O-:12].[CH3:13][NH2:14].O>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([NH:14][CH3:13])=[CH:4][N+:3]=1[O-:12]

Participants

5

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 707008042-Bromo-5-fluoro-4-nitropyridine 1-oxide

Product 1

HCID 866591292-Bromo-5-(methylamino)-4-nitropyridine 1-oxide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

2-Bromo-5-fluoro-4-nitropyridine 1-oxide (11.2 g, 47 mmol) and 2 N methylamine (solution in THF) (48 mL, 96 mmol) in 150 mL THF was stirred for 5 min at ambient temperature. Water was poured into the mixture and THF was removed i.vac. The solid was filtered, washed with water and dried at 50° C. i. vac.

Workup

  1. customwas removed i.vac
  2. filtrationThe solid was filtered
  3. washwashed with water
  4. customdried at 50° C. i

Sources & evidence

ORD record
ord-49b067ffd92e433f89895b16aa950197
Source dataset
uspto-grants-2013_12
Patent number
US08598190B2

Reaction notes

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