Hydrochloric Acid → HCID 121386661, compound

HRID 1908040Notes

Reaction equation

HRID 1908040 reaction equation
[N:1]1[N:5]2[C:6]3[CH:25]=[CH:24][CH:23]=[N:22][C:7]=3[O:8][C:9]3([CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]3)[C:4]2=[CH:3][CH:2]=1.[ClH:26].O1CCOCC1>C(Cl)Cl.CO>[ClH:26].[N:1]1[N:5]2[C:6]3[CH:25]=[CH:24][CH:23]=[N:22][C:7]=3[O:8][C:9]3([CH2:10][CH2:11][NH:12][CH2:13][CH2:14]3)[C:4]2=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58550888HCID 58550888, compound

Product 1

HCID 121386661HCID 121386661, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of tert-butyl spiro[piperidine-4,4′-pyrazolo[1,5-d]pyrido[2,3-b][1,4]oxazine]-1-carboxylate (35 mg, 0.10 mmol) in CH2Cl2 (1 mL) and MeOH (0.1 mL) was added HCl in dioxane (256 μL of 4 M, 1.02 mmol) and the mixture was stirred at 40° C. for 4 hours. The reaction mixture was evaporated and the hydrochloric acid salt of the product was used without further purification. ESI-MS m/z calc. 242.1. found 243.5 (M+1)+. Retention time: 0.32 minutes (3 min run).

Workup

  1. customThe reaction mixture was evaporated
  2. customthe hydrochloric acid salt of the product was used without further purification
  3. customRetention time: 0.32 minutes (3 min run)

Sources & evidence

ORD record
ord-1de0f2c94c68497b8dff5c1c42f3118e
Source dataset
uspto-grants-2013_12
Patent number
US08598164B2

Reaction notes

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