Hydrochloric Acid → HCID 67468372, compound

Participants

Reaction Steps

tert-Butyl spiro[imidazo[2,1-c][1,4]benzoxazine-4,4′-piperidine]-1′-carboxylate (138 mg, 0.40 mmol) was stirred for 10 min in 4M HCl in dioxane (2 mL of 4 M, 8.00 mmol). The reaction was evaporated to dryness to yield the spiro[benzo[b]imidazo[1,2-d][1,4]oxazine-4,4′-piperidine]dihydrochloride (97 mg, quantitative) that was used in next step without further purification. ESI-MS m/z calc. 241.1. found 242.3 (M+1)+. Retention time 0.40 minutes (3 min run).

Provenance & Evidence