Hydrochloric Acid → HCID 67468372, compound

HRID 1908052Notes

Reaction equation

HRID 1908052 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:6][CH2:5][C:4]2([C:11]3=[N:12][CH:13]=[CH:14][N:10]3[C:9]3[CH:15]=[CH:16][CH:17]=[CH:18][C:8]=3[O:7]2)[CH2:3][CH2:2]1.O1CCOCC1.[ClH:32]>>[ClH:32].[ClH:32].[NH:1]1[CH2:6][CH2:5][C:4]2([O:7][C:8]3[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=3[N:10]3[CH:14]=[CH:13][N:12]=[C:11]23)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58550791HCID 58550791, compound

Product 1

HCID 67468372HCID 67468372, compound

Procedure

tert-Butyl spiro[imidazo[2,1-c][1,4]benzoxazine-4,4′-piperidine]-1′-carboxylate (138 mg, 0.40 mmol) was stirred for 10 min in 4M HCl in dioxane (2 mL of 4 M, 8.00 mmol). The reaction was evaporated to dryness to yield the spiro[benzo[b]imidazo[1,2-d][1,4]oxazine-4,4′-piperidine]dihydrochloride (97 mg, quantitative) that was used in next step without further purification. ESI-MS m/z calc. 241.1. found 242.3 (M+1)+. Retention time 0.40 minutes (3 min run).

Workup

  1. customThe reaction was evaporated to dryness

Sources & evidence

ORD record
ord-ddafe7299ae745689f6845f0b0729a96
Source dataset
uspto-grants-2013_12
Patent number
US08598164B2

Reaction notes

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