Hydrochloric Acid → HCID 86635141, compound

Participants

Reaction Steps

A mixture of [4-(6-chloro-pyrimidin-4-yl)-phenyl]-carbamic acid tert-butyl ester (918 mg, 3.00 mmol), CH2Cl2 (30 mL) and HCl (4 N in dioxane; 3.80 mL) was stirred overnight at rt and the solid isolated by filtration. The resultant solid was taken up in water, treated with satd. aq. NaHCO3 and extracted with CH2Cl2. The extract was dried, filtered, and concentrated. The material was used directly in Step C.

Provenance & Evidence