Hydrochloric Acid → HCID 86635141, compound

HRID 1908250Notes

Reaction equation

HRID 1908250 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([Cl:20])[N:17]=[CH:16][N:15]=2)=[CH:10][CH:9]=1)(C)(C)C.C(Cl)Cl.Cl>O>[Cl:20][C:18]1[N:17]=[CH:16][N:15]=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([NH2:7])=[CH:9][CH:10]=2)[CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 24902045HCID 24902045, compound

Product 1

HCID 86635141HCID 86635141, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of [4-(6-chloro-pyrimidin-4-yl)-phenyl]-carbamic acid tert-butyl ester (918 mg, 3.00 mmol), CH2Cl2 (30 mL) and HCl (4 N in dioxane; 3.80 mL) was stirred overnight at rt and the solid isolated by filtration. The resultant solid was taken up in water, treated with satd. aq. NaHCO3 and extracted with CH2Cl2. The extract was dried, filtered, and concentrated. The material was used directly in Step C.

Workup

  1. customthe solid isolated by filtration
  2. additiontreated with satd
  3. extractionaq. NaHCO3 and extracted with CH2Cl2
  4. customThe extract was dried
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-fc3f26b6e844426f89d3f49463fc849f
Source dataset
uspto-grants-2013_12
Patent number
US08598202B2

Reaction notes

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