反应详情

温度

64 °C

To a stirred rt suspension consisting of 2-azido-1-(4-methylsulfanyl-phenyl)-ethanol (104.6 mg, 0.50 mmol), 10% Pd/C (100 mg, 0.10 mmol) and MeOH (25 mL) was added ammonium formate (316 mg, 5.0 mmol) under a N2 atmosphere. The resulting mixture was heated at 64° C. for 2 h. After cooling to rt, the catalyst was removed by filtration through a pad of celite and the celite pad washed with MeOH. The filtrate was concentrated and purified (FCC) to yield the title compound (66 mg, 72%).

1. customTo a stirred rt
2. temperatureAfter cooling to rt
3. customthe catalyst was removed by filtration through a pad of celite
4. washthe celite pad washed with MeOH
5. concentrationThe filtrate was concentrated
6. custompurified (FCC)