HRID1908265

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3159614

3-(pyridin-2-yl)propan-1-amine

C8H12N2

结构：O=C(NC(Cc1ccccc1)C(O)C(=O)O)c1cccnc1-n1ccc(-c2ccc(F)cc2)n1

HCID67239352

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(Cc1ccccc1)C(O)C(=O)NCCCc1ccccn1)c1cccnc1-n1ccc(-c2ccc(F)cc2)n1

HCID67239669

未命名化合物

PROCEDURE

实验过程

The reaction was carried out in analogy to reaction step 1.3 by reacting 3-(2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-phenylbutanoic acid with 3-(pyridin-2-yl)propylamine; ESI-MS [M+H]+: 579.2.

WORKUP

后处理

customThe reaction was carried out in analogy to reaction step 1.3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0fd5235f5692418dac54988ed533bccd
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08598211B2
来源说明: uspto-grants-2013_12

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][N:10]([C:13]3[N:34]=[CH:33][CH:32]=[CH:31][C:14]=3[C:15]([NH:17][CH:18]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:19]([OH:23])[C:20]([OH:22])=O)=[O:16])[N:9]=2)=[CH:4][CH:3]=1.[N:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[CH2:41][CH2:42][CH2:43][NH2:44]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:12]=[CH:11][N:10]([C:13]3[N:34]=[CH:33][CH:32]=[CH:31][C:14]=3[C:15]([NH:17][CH:18]([CH:19]([OH:23])[C:20](=[O:22])[NH:44][CH2:43][CH2:42][CH2:41][C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][N:35]=3)[CH2:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[O:16])[N:9]=2)=[CH:6][CH:7]=1