(R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid → Ethyl 3-((R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

HRID 1908282Notes

Reaction equation

HRID 1908282 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[C:9](=[O:10])[CH2:8][CH2:7][C@@H:6]1[C:11]([OH:13])=O.[Cl-].[CH2:19]([O:21][C:22](=[O:34])[CH:23]([OH:33])[CH:24]([NH3+:32])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:20]>>[F:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[C:9](=[O:10])[CH2:8][CH2:7][C@@H:6]1[C:11]([NH:32][CH:24]([CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH:23]([OH:33])[C:22]([O:21][CH2:19][CH3:20])=[O:34])=[O:13]

Participants

3

Reactant 2

HCID 42127382(R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acidHCID 86644788HCID 86644788, compound

Product 1

HCID 67095178Ethyl 3-((R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

Procedure

The reaction was carried out in analogy to reaction of step 1.1 by reacting (R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxylic acid and 4-ethoxy-3-hydroxy-4-oxo-1-phenylbutan-2-aminium chloride. ESI-MS [M+H]+=443.2.

Workup

  1. customThe reaction was carried out in analogy to reaction of step 1.1

Sources & evidence

ORD record
ord-24cfa6335adf4e2784ccdc069d9cfd64
Source dataset
uspto-grants-2013_12
Patent number
US08598211B2

Reaction notes

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