Hydrochloric Acid → HCID 178490914, compound

Participants

Reaction Steps

To a solution of 300 mg of 5-Hydroxy-1-(3-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester in 5 ml of THF, 1 ml of a 1 M aqueous NaOH solution was added. After 3 h the reaction was acidified to pH 1 with diluted aqueous hydrochloric acid and the organic solvents was removed under reduced pressure. The precipitated product was collected by filtration and was used in the subsequent reaction. Yield: 267 mg.

Provenance & Evidence