Hydrochloric Acid → HCID 178490914, compound

HRID 1908609Notes

Reaction equation

HRID 1908609 reaction equation
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([OH:11])[N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)[N:7]=1)=[O:5])C.[OH-].[Na+].Cl>C1COCC1>[OH:11][C:9]1[N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)[N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178469355HCID 178469355, compound

Product 1

HCID 178490914HCID 178490914, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 300 mg of 5-Hydroxy-1-(3-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester in 5 ml of THF, 1 ml of a 1 M aqueous NaOH solution was added. After 3 h the reaction was acidified to pH 1 with diluted aqueous hydrochloric acid and the organic solvents was removed under reduced pressure. The precipitated product was collected by filtration and was used in the subsequent reaction. Yield: 267 mg.

Workup

  1. customthe organic solvents was removed under reduced pressure
  2. filtrationThe precipitated product was collected by filtration
  3. customwas used in the subsequent reaction

Sources & evidence

ORD record
ord-d18a698ece634cbb95658a3cd68f8f08
Source dataset
uspto-grants-2013_12
Patent number
US08598179B2

Reaction notes

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