HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178501468, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | AmbotzHAA6700 | HCID 7016385 | — |
| Reactant | 5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid | HCID 9167391 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178501468 | HCID 178501468 | — |
Reaction Steps
To a solution of 12.1 g 1-phenyl-3-carboxy-5-pyrazolone, 15 g (S)-2-amino-pentanedioic acid 5-tert-butyl ester 1-methyl ester and 22.5 g HATU in 200 ml DCM were added 34 ml triethylamine. After 2 h the mixture was extracted with water and the crude product obtained after evaporation of the solvent reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598179B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-31fbe8cbac834632bdc69c94605dcef1 |
| Source note | uspto-grants-2013_12 |