反应详情

To a solution of 12.1 g 1-phenyl-3-carboxy-5-pyrazolone, 15 g (S)-2-amino-pentanedioic acid 5-tert-butyl ester 1-methyl ester and 22.5 g HATU in 200 ml DCM were added 34 ml triethylamine. After 2 h the mixture was extracted with water and the crude product obtained after evaporation of the solvent reacted without further purification.

1. extractionAfter 2 h the mixture was extracted with water