Cyclohexanone → HCID 16682041, compound

HRID 1908699Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[C:11]1(=O)[CH2:15][CH2:14][CH2:13][CH2:12]1.[C:17]1(=O)CCCCC1>>[CH3:17][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[O:1][C:11]1([CH2:15][CH2:14][CH2:13][CH2:12]1)[CH2:9][C:8]2=[O:10]

Participants

Reactant 3

HCID 7967Cyclohexanone

HCID 83752'-Hydroxyacetophenone

HCID 8452Cyclopentanone

Product 1

HCID 16682041HCID 16682041, compound

Procedure

The title compound was prepared using the procedure as described in Example 1A, substituting 2′-hydroxy-5′-methylacetophenone (Aldrich, CAS#1450-72-2) for 2′-hydroxyacetophenone and cyclopentanone for cyclohexanone. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.51 (m, 1H), 7.35 (m, 1H), 6.87 (d, J=8.5 Hz, 1H), 2.85 (s, 2H), 2.26 (s, 3H), 1.89-1.95 (m, 2H), 1.59-1.79 (m, 6H). MS (DCI+) m/z 217 (M+H), 234 (M+NH4).

Sources & evidence

ORD record: ord-b91c57f85521455d8a184094d3f04312
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598220B2

Reaction notes

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