Water → DL-3-n-Butylphthalide

HRID 1908705Notes

Reaction equation

HRID 1908705 reaction equation
C[C@:2]12[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[C@H:10](N1)C[C:8]1[CH:7]=[CH:6]C=C[C:3]2=1.[Cl-].C1(N2C=[NH+]N(C3C=CC=CC=3)N2C2C=CC=CC=2)C=CC=CC=1.[OH2:42].[Cl-].[Na+].[OH2:45]>>[CH2:3]([CH:2]1[C:13]2[C:12](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10](=[O:45])[O:42]1)[CH2:8][CH2:7][CH3:6]

Participants

5

Reactant 4

HCID 962WaterHCID 180081DizocilpineHCID 57417360Sodium chloride; waterHCID 153982335HCID 153982335, compound

Product 1

HCID 61361DL-3-n-Butylphthalide

Procedure

l-, d-, and dl-NBP were all provided by department of synthetic pharmaceutical chemistry of our institute, both optical and chemical purity of which are >99%, and the optical activity of which is −66.49°, +66.88° and 0°, respectively. They were formulated with vegetable oil. MK801 is the product of Sigma, and was formulated with physiological brine. Triphenyltetrazolium chloride (TTC), which was manufactured by Beijing Chemical Plant, was formulated with distilled water into 4% solution for use.

Workup

  1. customall provided by department of synthetic pharmaceutical chemistry of our institute
  2. customis −66.49°, +66.88° and 0°

Sources & evidence

ORD record
ord-ef7c642962334a5599037f1bc5a16e14
Source dataset
uspto-grants-2013_12
Patent number
US08598225B2

Reaction notes

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