Hydrochloric Acid → HCID 67027083, compound

HRID 1908712Notes

Reaction equation

HRID 1908712 reaction equation
C[O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([CH2:11][OH:12])[CH:5]=1.[ClH:14]>>[ClH:14].[OH:12][CH2:11][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([CH3:10])[N:7]=1)[C:3]([OH:13])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67026976HCID 67026976, compound

Product 1

HCID 67027083HCID 67027083, compound

Procedure

A solution of 2-hydroxymethyl-6-methyl-isonicotinic acid methyl ester (500 mg, 2.76 mmol) in 32% aq. HCl (10 mL) is stirred at 60° C. for 5 h. The solvent is removed and the residue is dried to give 2-hydroxymethyl-6-methyl-isonicotinic acid hydrochloride (480 mg) as a yellow solid; LC-MS: tR=0.15 min, [M+1]+=168.04.

Workup

  1. customThe solvent is removed
  2. customthe residue is dried

Sources & evidence

ORD record
ord-44fd5ecf194f4b43bc6e1cc5abd7a8d1
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

Loading…