Hydrochloric Acid → HCID 67026961, compound

HRID 1908721Notes

Reaction equation

HRID 1908721 reaction equation
C([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[N:8]=[C:7]([CH3:15])[CH:6]=1)C.[ClH:17]>>[ClH:17].[CH3:15][C:7]1[CH:6]=[C:5]([CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[N:8]=1)[C:4]([OH:16])=[O:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 574372012-Methyl-6-(2-methyl-propyl)-isonicotinic acid ethyl ester

Product 1

HCID 67026961HCID 67026961, compound

Procedure

A solution of 2-methyl-6-(2-methyl-propyl)-isonicotinic acid ethyl ester (9.78 g, 45.1 mmol) in 6 N aq. HCl (20 mL) is stirred at 95° C. for 20 h before the solvent is evaporated. The residue is dried under HV to give 2-methyl-6-(2-methyl-propyl)-isonicotinic acid hydrochloride (9.56 g) as a colourless solid, LC-MS: tR=0.52 min.

Workup

  1. customis evaporated
  2. customThe residue is dried under HV

Sources & evidence

ORD record
ord-4896bebd7a154c2daaacd4d400d9c894
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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