Hydrochloric Acid → HCID 67387774, compound

Participants

Reaction Steps

A solution of 2-hydroxymethyl-6-isobutyl-isonicotinic acid ethyl ester (100 mg, 0.421 mmol) in 25% aq. HCl (5 mL) is stirred at 75° C. for 16 h. The solvent is removed in vacuo and the remaining residue is dried under HV to give 2-hydroxymethyl-6-isobutyl-isonicotinic acid hydrochloride (100 mg) as an oil; LC-MS: tR=0.52 min, [M+1]+=210.47.

Provenance & Evidence