Hydrochloric Acid → HCID 67387774, compound

HRID 1908724Notes

Reaction equation

HRID 1908724 reaction equation
C([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[N:8]=[C:7]([CH2:15][OH:16])[CH:6]=1)C.[ClH:18]>>[ClH:18].[OH:16][CH2:15][C:7]1[CH:6]=[C:5]([CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[N:8]=1)[C:4]([OH:17])=[O:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67027010HCID 67027010, compound

Product 1

HCID 67387774HCID 67387774, compound

Procedure

A solution of 2-hydroxymethyl-6-isobutyl-isonicotinic acid ethyl ester (100 mg, 0.421 mmol) in 25% aq. HCl (5 mL) is stirred at 75° C. for 16 h. The solvent is removed in vacuo and the remaining residue is dried under HV to give 2-hydroxymethyl-6-isobutyl-isonicotinic acid hydrochloride (100 mg) as an oil; LC-MS: tR=0.52 min, [M+1]+=210.47.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe remaining residue is dried under HV

Sources & evidence

ORD record
ord-2052bb9f50a64207865cc3f2fc5abca8
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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