Hydrochloric Acid → HCID 67027150, compound

HRID 1908728Notes

Reaction equation

HRID 1908728 reaction equation
C([O:3][C:4](=[O:17])[C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:6]=1)C.[ClH:18]>>[ClH:18].[CH:12]1([C:7]2[CH:6]=[C:5]([CH:10]=[C:9]([CH3:11])[N:8]=2)[C:4]([OH:17])=[O:3])[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67026923HCID 67026923, compound

Product 1

HCID 67027150HCID 67027150, compound

Procedure

A solution of 2-cyclopentyl-6-methyl-isonicotinic acid ethyl ester (3.96 g, 17.0 mmol) in 25% aq. HCl (50 mL) is stirred at 75° C. for 16 h. The solvent is removed in vacuo and the remaining residue is dried under HV to give 2-cyclopentyl-6-methyl-isonicotinic acid hydrochloride (4.12 mg) as a white solid; LC-MS: tR=0.54 min, [M+1]+=206.08.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe remaining residue is dried under HV

Sources & evidence

ORD record
ord-5c4ea868cb824d22aca2d44ad5734aec
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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