HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Ethyl-6-isobutyl-isonicotinic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Ethyl-6-isobutylisonicotinic acid tert-butyl ester | HCID 67027114 | — |
| Product | 2-Ethyl-6-isobutyl-isonicotinic acid hydrochloride | HCID 67388242 | — |
Reaction Steps
A solution of 2-ethyl-6-isobutyl-isonicotinic acid tert-butyl ester (391 mg, 1.49 mmol) in 6 N aq. HCl (15 mL) is stirred at 65° C. for 2 days before the solvent is evaporated. The residue is dried under HV to give 2-ethyl-6-isobutyl-isonicotinic acid hydrochloride (334 mg) as a colourless solid, LC-MS: tR=0.58 min, [M+1]+=208.04.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598208B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bfed085f5ab844888d691eb3978d8fe5 |
| Source note | uspto-grants-2013_12 |