Hydrochloric Acid → 2-Ethyl-6-isobutyl-isonicotinic acid hydrochloride

HRID 1908733Notes

Reaction equation

HRID 1908733 reaction equation
C([O:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:10]=[C:9]([CH2:17][CH3:18])[CH:8]=1)(C)(C)C.[ClH:20]>>[ClH:20].[CH2:17]([C:9]1[CH:8]=[C:7]([CH:12]=[C:11]([CH2:13][CH:14]([CH3:15])[CH3:16])[N:10]=1)[C:6]([OH:19])=[O:5])[CH3:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 670271142-Ethyl-6-isobutylisonicotinic acid tert-butyl ester

Product 1

HCID 673882422-Ethyl-6-isobutyl-isonicotinic acid hydrochloride

Procedure

A solution of 2-ethyl-6-isobutyl-isonicotinic acid tert-butyl ester (391 mg, 1.49 mmol) in 6 N aq. HCl (15 mL) is stirred at 65° C. for 2 days before the solvent is evaporated. The residue is dried under HV to give 2-ethyl-6-isobutyl-isonicotinic acid hydrochloride (334 mg) as a colourless solid, LC-MS: tR=0.58 min, [M+1]+=208.04.

Workup

  1. customis evaporated
  2. customThe residue is dried under HV

Sources & evidence

ORD record
ord-bfed085f5ab844888d691eb3978d8fe5
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

Loading…