2-Chloro-6-methylpyridine-4-carboxylic acid → HCID 58418080, compound

HRID 1908735Notes

Reaction equation

HRID 1908735 reaction equation
Cl[C:2]1C=C(C=C(C)N=1)C(O)=O.[CH2:12]([O:14][C:15]1[CH:16]=[C:17]([CH:21]=[C:22]([CH3:24])[N:23]=1)[C:18]([OH:20])=[O:19])[CH3:13]>C(O)(C)C>[CH:12]([O:14][C:15]1[CH:16]=[C:17]([CH:21]=[C:22]([CH3:24])[N:23]=1)[C:18]([OH:20])=[O:19])([CH3:2])[CH3:13]

Participants

4

Reactant 2

HCID 1412092-Chloro-6-methylpyridine-4-carboxylic acidHCID 58418014HCID 58418014, compound

Product 1

HCID 58418080HCID 58418080, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-Isopropoxy-6-methyl-isonicotinic acid is prepared starting from 2-chloro-6-methyl-isonicotinic acid in analogy to 2-ethoxy-6-methyl-isonicotinic acid using isopropanol as solvent; LC-MS: tR=0.70 min, [M+1]+=196.04.

Sources & evidence

ORD record
ord-b090730b0a0840c7af7c5cde06cfed4d
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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