Hydrochloric Acid → HCID 67026906, compound

HRID 1908738Notes

Reaction equation

HRID 1908738 reaction equation
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([CH2:12][CH:13]([CH3:15])[CH3:14])[CH:5]=1.[ClH:17]>>[ClH:17].[CH2:12]([C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH3:11])[N:7]=1)[C:3]([OH:16])=[O:2])[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67026994HCID 67026994, compound

Product 1

HCID 67026906HCID 67026906, compound

Procedure

A solution of 2-isobutyl-6-methoxy-isonicotinic acid methyl ester (1.20 g, 5.38 mmol) in 25% aq. HCl (60 mL) is stirred at 65° C. for 16 h. The solvent is removed in vacuo and the residue is dried under HV to give 2-isobutyl-6-methoxy-isonicotinic acid hydrochloride (1.20 g) as a solid; LC-MS*: tR=0.48 min, [M+1]+=210.1.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is dried under HV

Sources & evidence

ORD record
ord-1ab4753ff86e4da58ca5bc7b6cb10887
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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