Hydrochloric Acid → HCID 67027015, compound

HRID 1908768Notes

Reaction equation

HRID 1908768 reaction equation
C([O:5][C:6](=[O:17])[C:7]1[CH:12]=[C:11]([CH2:13][CH3:14])[C:10]([CH2:15][CH3:16])=[N:9][CH:8]=1)(C)(C)C.[ClH:18]>>[ClH:18].[CH2:13]([C:11]1[C:10]([CH2:15][CH3:16])=[N:9][CH:8]=[C:7]([CH:12]=1)[C:6]([OH:17])=[O:5])[CH3:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67027121HCID 67027121, compound

Product 1

HCID 67027015HCID 67027015, compound

Procedure

A solution of 5,6-diethyl-nicotinic acid tert-butyl ester (860 mg, 3.65 mmol) in 6 N aq. HCl (15 mL) is stirred at 65° C. for 3 h before the solvent is evaporated. The residue is dried under HV to give 5,6-diethyl-nicotinic acid hydrochloride (923 mg) as an oil; LC-MS: tR=0.50 min, [M+1]+=180.05.

Workup

  1. customis evaporated
  2. customThe residue is dried under HV

Sources & evidence

ORD record
ord-ffe1c35fdff743d5bcf5123aa700ea76
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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