HCID 58418052, compound → HCID 58418008, compound

HRID 1908769Notes

Reaction equation

HRID 1908769 reaction equation
[CH2:1]([C:3]1[C:4](CC)=NC=C([CH:11]=1)C(O)=O)C.C([O:18][C:19](=[O:29])[C:20]1[CH:25]=[C:24](Cl)[C:23]([CH:27]=[CH2:28])=[N:22][CH:21]=1)(C)(C)C>>[CH2:27]([C:23]1[C:24]([CH2:1][CH:3]([CH3:4])[CH3:11])=[CH:25][C:20]([C:19]([OH:18])=[O:29])=[CH:21][N:22]=1)[CH3:28]

Participants

3

Reactant 2

HCID 58418052HCID 58418052, compoundHCID 67026909HCID 67026909, compound

Product 1

HCID 58418008HCID 58418008, compound

Procedure

6-Ethyl-5-isobutyl-nicotinic acid is prepared in analogy to 5,6-diethyl-nicotinic acid from 5-chloro-6-vinyl-nicotinic acid tert.-butyl ester and 2,4,6-tri-(2-methyl-propenyl)-cycloboroxane pyridine complex (prepared in analogy to a procedure given by F. Kerins, D. F. O'Shea, J. Org. Chem. 67 (2002) 4968-4971); LC-MS: tR=0.64 min, [M+1]+=207.98.

Workup

  1. customprepared in analogy to a procedure

Sources & evidence

ORD record
ord-de02c2d9859a4158a781da1526d5d927
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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