Hydrochloric Acid → HCID 67027156, compound

HRID 1908772Notes

Reaction equation

HRID 1908772 reaction equation
C([O:3][C:4](=[O:19])[C:5]1[CH:10]=[C:9]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8]([CH2:15][CH:16]([CH3:18])[CH3:17])=[N:7][CH:6]=1)C.[ClH:20]>>[ClH:20].[CH2:11]([C:9]1[C:8]([CH2:15][CH:16]([CH3:18])[CH3:17])=[N:7][CH:6]=[C:5]([CH:10]=1)[C:4]([OH:19])=[O:3])[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67027012HCID 67027012, compound

Product 1

HCID 67027156HCID 67027156, compound

Procedure

A solution of 5,6-diisobutyl-nicotinic acid ethyl ester (52 mg, 0.2 mmol) in 6 N aq. HCl (2 mL) is stirred at 65° C. for 15 h before it is cooled to rt and extracted with diethyl ether (2×10 mL). The aq. phase is evaporated and the residue is dried under HV to give 5,6-diisobutyl-nicotinic acid hydrochloride (0.12 g) as a colourless solid; LC-MS: tR=0.73 min, [M+1]+=236.40.

Workup

  1. extractionextracted with diethyl ether (2×10 mL)
  2. customThe aq. phase is evaporated
  3. customthe residue is dried under HV

Sources & evidence

ORD record
ord-4c19bdee19434821a91965ed8a8a4d67
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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