Hydrochloric Acid → 6-Isobutyl-5-methyl-nicotinic acid hydrochloride

HRID 1908777Notes

Reaction equation

HRID 1908777 reaction equation
C([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([CH2:12][CH:13]([CH3:15])[CH3:14])=[N:7][CH:6]=1)C.[ClH:17]>>[ClH:17].[CH2:12]([C:8]1[C:9]([CH3:11])=[CH:10][C:5]([C:4]([OH:16])=[O:3])=[CH:6][N:7]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 574372006-Isobutyl-5-methylnicotinic acid ethyl ester

Product 1

HCID 670271826-Isobutyl-5-methyl-nicotinic acid hydrochloride

Procedure

A solution of 6-isobutyl-5-methyl-nicotinic acid ethyl ester (3.75 g, 16.95 mmol) in 12.5% aq. HCl (50 mL) is stirred at 65° C. for 24 h before the solvent is evaporated. The residue is dried under HV to give 6-isobutyl-5-methyl-nicotinic acid hydrochloride (3.55 g) as a white powder; LC-MS: tR=0.57 min, [M+1]+=194.25.

Workup

  1. customis evaporated
  2. customThe residue is dried under HV

Sources & evidence

ORD record
ord-785b0e3d8577400fa7238f6ef3adfa70
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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