Hydrochloric Acid → HCID 67026965, compound

HRID 1908807Notes

Reaction equation

HRID 1908807 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]([CH2:13][CH:14]([CH3:16])[CH3:15])[N:7]=1)=[O:5])C.[ClH:17]>>[ClH:17].[CH2:13]([C:8]1[N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:11]=[C:10]([CH3:12])[CH:9]=1)[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66933548HCID 66933548, compound

Product 1

HCID 67026965HCID 67026965, compound

Procedure

A solution of 6-isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl ester (174 mg, 0.78 mmol) in 6 N aq. HCl (20 mL) is stirred at 65° C. for 18 h. The solvent is evaporated and the remaining residue is dried under HV to give give 6-isobutyl-4-methyl-pyridine-2-carboxylic acid hydrochloride as green oil; LC-MS: tR=0.58 min, [M+1]+=194.09.

Workup

  1. customThe solvent is evaporated
  2. customthe remaining residue is dried under HV
  3. customto give

Sources & evidence

ORD record
ord-53d92ae3bbf944338c5bbe6fc2cf3cd9
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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