2-Isopropyl-6-methylisonicotinic acid ethyl ester → HCID 178426662, compound

HRID 1908829Notes

Reaction equation

HRID 1908829 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:6]([NH:8][OH:9])=[NH:7])[CH3:2].[CH2:14](OC(=O)C1C=C(C)N=C(C(C)C)C=1)C>>[OH:9][NH:8][C:6](=[NH:7])[C:5]1[CH:10]=[C:11]([CH3:13])[N:12]=[C:3]([CH:1]([CH3:14])[CH3:2])[CH:4]=1

Participants

3

Reactant 2

HCID 669335042-Isopropyl-6-methylisonicotinic acid ethyl esterHCID 178436634HCID 178436634, compound

Product 1

HCID 178426662HCID 178426662, compound

Procedure

The title compound is prepared in analogy to 2-ethyl-N-hydroxy-6-methyl-isonicotinamidine starting from 2-isopropyl-6-methyl-isonicotinic acid ethyl ester; LC-MS: tR=0.42 min, [M+1]+=194.08; 1H NMR (D6-DMSO): δ 1.22 (d, J=7.0 Hz, 6H), 2.44 (s, 3H), 2.91-3.02 (hept, J=7.0 Hz, 1H), 5.91 (s, 2H), 7.32 (s, 2H), 9.88 (s, 1H).

Sources & evidence

ORD record
ord-c260c0e5e4a748dab9b39eeec628bbc0
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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