反应详情

5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester is prepared in analogy to 5-isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl ester starting from 2,5-dibromo-4-picoline; LC-MS: tR=0.70 min, [M+1]+=193.99; 1H NMR (CDCl3): δ 1.25 (t, J=7.8 Hz, 3H), 1.45 (t, J=7.0 Hz, 3H), 2.39 (s, 3H), 2.72 (q, J=7.5 Hz, 2H), 4.48 (q, J=7.0 Hz, 2H), 7.92 (s, 1H), 8.49 (s, 1H).