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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1908839Generated: October 27, 2026

2,5-Dibromo-4-methylpyridine → 5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester

https://huagongshe.com/reaction/1908839

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-Dibromo-4-methylpyridineHCID 2734429—
Reactant5-Isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl esterHCID 67027029—
Product5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl esterHCID 67027141—

Reaction Steps

5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester is prepared in analogy to 5-isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl ester starting from 2,5-dibromo-4-picoline; LC-MS: tR=0.70 min, [M+1]+=193.99; 1H NMR (CDCl3): δ 1.25 (t, J=7.8 Hz, 3H), 1.45 (t, J=7.0 Hz, 3H), 2.39 (s, 3H), 2.72 (q, J=7.5 Hz, 2H), 4.48 (q, J=7.0 Hz, 2H), 7.92 (s, 1H), 8.49 (s, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08598208B2
Source datasetuspto-grants-2013_12
ORD IDord-67219aa058c045f398a14fde33328a79
Source noteuspto-grants-2013_12