HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dibromo-4-methylpyridine → 5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dibromo-4-methylpyridine | HCID 2734429 | — |
| Reactant | 5-Isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl ester | HCID 67027029 | — |
| Product | 5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester | HCID 67027141 | — |
Reaction Steps
5-Ethyl-4-methyl-pyridine-2-carboxylic acid ethyl ester is prepared in analogy to 5-isobutyl-4-methyl-pyridine-2-carboxylic acid ethyl ester starting from 2,5-dibromo-4-picoline; LC-MS: tR=0.70 min, [M+1]+=193.99; 1H NMR (CDCl3): δ 1.25 (t, J=7.8 Hz, 3H), 1.45 (t, J=7.0 Hz, 3H), 2.39 (s, 3H), 2.72 (q, J=7.5 Hz, 2H), 4.48 (q, J=7.0 Hz, 2H), 7.92 (s, 1H), 8.49 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598208B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-67219aa058c045f398a14fde33328a79 |
| Source note | uspto-grants-2013_12 |