6-Bromo-4-methoxy-2-pyridinecarboxylic acid → HCID 86657321, compound

HRID 1908859Notes

Reaction equation

HRID 1908859 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[C:4]([O:11][CH3:12])[CH:3]=1.O[NH:14][C:15](=[NH:24])[C:16]1[CH:21]=[C:20]([CH3:22])[N:19]=[C:18]([CH3:23])[CH:17]=1>>[Br:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[C:6]([C:8]2[O:10][N:24]=[C:15]([C:16]3[CH:21]=[C:20]([CH3:22])[N:19]=[C:18]([CH3:23])[CH:17]=3)[N:14]=2)[N:7]=1

Participants

3

Reactant 2

HCID 584180076-Bromo-4-methoxy-2-pyridinecarboxylic acidHCID 178426670HCID 178426670, compound

Product 1

HCID 86657321HCID 86657321, compoundYield 10.3%

Procedure

2-Bromo-6-[3-(2,6-dimethyl-4-pyridinyl)-[1,2,4]oxadiazol-5-yl]-4-methoxy-pyridine (24 mg) is prepared following the general method for the preparation of 3,5-dipyridyl-[1,2,4]oxadiazoles starting from 6-bromo-4-methoxy-pyridine-2-carboxylic acid (150 mg, 0646 mmol) and N-hydroxy-2,6-dimethyl-isonicotinamidine (107 mg, 0.646 mmol); LC-MS: tR=0.76 min, [M+1]+=360.91.

Sources & evidence

ORD record
ord-84b9dcd76b1e40bdabf2158a9721c5fc
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

Loading…