反应详情

50 g of Diacerein containing about 500 ppm of genotoxic impurities are suspended in 750 ml of acetone and 50 ml of water and, under magnetic agitation, 25 ml of triethylamine diluted with 100 ml of acetone are added over a period of 3 hours keeping pH not more than 7, until complete dissolution. The obtained solution is treated with 32 g of potassium ethyl hexanoate in 260 ml of acetone, over a period of 2 hours. The obtained precipitate is filtered, washed with 500 ml of acetone and dried under vacuum at 40° C. for one night. 50 g of potassium Diacerein salt is obtained.

1. additionare added over a period of 3 hours
2. dissolutionuntil complete dissolution
3. filtrationThe obtained precipitate is filtered
4. washwashed with 500 ml of acetone
5. customdried under vacuum at 40° C. for one night