Ammonia → N-ethyl-2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-5,6,7,8-tetrahydro-4H-5,8-epoxycyclohepta[b]thiophene-3-carboxamide

HRID 1908933Notes

Reaction equation

[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]2[CH:10]3[O:20][CH:13]([CH2:14][C:15]=2[C:16]=1[C:17](O)=[O:18])[CH2:12][CH2:11]3)=[O:5].[CH2:29]([NH2:31])[CH3:30].N>>[CH2:29]([NH:31][C:17]([C:16]1[C:15]2[CH2:14][CH:13]3[O:20][CH:10]([CH2:11][CH2:12]3)[C:9]=2[S:8][C:7]=1[NH:6][C:4](=[O:5])[C:3]1[C:21]([C:25]([F:26])([F:28])[F:27])=[CH:22][CH:23]=[CH:24][C:2]=1[F:1])=[O:18])[CH3:30]

Participants

Reactant 3

HCID 222Ammonia

HCID 6341Ethylamine

HCID 668459064-(2-Fluoro-6-trifluoromethyl-benzoylamino)-11-oxa-3-thia-tricyclo[6.2.1.02,6]undeca-2(6),4-diene-5-carboxylic acid

Product 1

HCID 25002740N-ethyl-2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-5,6,7,8-tetrahydro-4H-5,8-epoxycyclohepta[b]thiophene-3-carboxamide

Procedure

The title compound was prepared from the product of Example 4A and ethylamine according to the procedure described for Example 4B. MS (DCI/NH3) m/z 443 (M+H)+.

Sources & evidence

ORD record: ord-46efbadbfc96474d97ac1f3f76510a98
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598224B2

Reaction notes

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