Hydrogen Bromide → HCID 67140438, compound

HRID 1908947Notes

Reaction equation

HRID 1908947 reaction equation
C([O:3][C:4](=[O:36])[C:5]([NH:32]C(=O)C)([CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16](C(OC(C)(C)C)=O)[C:17]3[C:22]([C:23]=2[CH:24]=1)=[CH:21][CH:20]=[CH:19][CH:18]=3)C(OCC)=O)C.Br>>[NH2:32][CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[NH:16][C:17]3[C:22]([C:23]=2[CH:24]=1)=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:4]([OH:36])=[O:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59814445HCID 59814445, compound

Product 1

HCID 67140438HCID 67140438, compound

Procedure

2-Acetylamino-2-(9-tert-butoxycarbonyl-9H-carbazol-3-ylmethyl)-malonic acid diethyl ester (200 mg, 0.4 mmol) was combined with hydrogen bromide (4 mL of a 24% aqueous solution) and refluxed for about 12 h. The cooled reaction mixture was evaporated under reduced pressure and dried under high vacuum to afford the amino acid as the hydrogen bromide salt. ES-MS (M+H)+ 255.0 (calc. 254.1).

Workup

  1. temperaturerefluxed for about 12 h
  2. customThe cooled reaction mixture
  3. customwas evaporated under reduced pressure
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-a5cb7f2b634242d7ad3da3a133f8d931
Source dataset
uspto-grants-2013_12
Patent number
US08598312B2

Reaction notes

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