Di-para-toluoyl-L-tartaric acid → HCID 131731065, compound

HRID 1908967Notes

Reaction equation

HRID 1908967 reaction equation
[C:1]([O:5][CH2:6][C@H:7]1[NH:12][CH2:11][CH2:10][NH:9][C:8]1=[O:13])([CH3:4])([CH3:3])[CH3:2].[C:14]1([CH3:41])[CH:19]=[CH:18][C:17]([C:20]([C@@:22]([C:38]([OH:40])=[O:39])([OH:37])[C@@:23]([C:28]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][CH:31]=2)=[O:29])([OH:27])[C:24]([OH:26])=[O:25])=[O:21])=[CH:16][CH:15]=1>CC(C)=O>[C:14]1([CH3:41])[CH:19]=[CH:18][C:17]([C:20]([C@@:22]([C:38]([OH:40])=[O:39])([OH:37])[C@@:23]([C:28]([C:30]2[CH:31]=[CH:32][C:33]([CH3:36])=[CH:34][CH:35]=2)=[O:29])([OH:27])[C:24]([OH:26])=[O:25])=[O:21])=[CH:16][CH:15]=1.[C:1]([O:5][CH2:6][C@H:7]1[NH:12][CH2:11][CH2:10][NH:9][C:8]1=[O:13])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 29414711Di-para-toluoyl-L-tartaric acidHCID 58058025HCID 58058025, compound

Product 1

HCID 131731065HCID 131731065, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution that was prepared by dissolving 100.0 g of (R)-3-(t-butoxymethyl)piperazine-2-one to 500 mL of acetone, and then by dissolving 207.4 g of di-p-toluoyl-L-tartaric acid to 700 mL of acetone was slowly added to a reactor. The resulting reaction solution was stirred for 1 hour, and then resulting solid was filtered to obtain 251.4 g of a title compound.

Workup

  1. customA solution that was prepared
  2. additionwas slowly added to a reactor
  3. customThe resulting reaction solution
  4. customresulting solid
  5. filtrationwas filtered

Sources & evidence

ORD record
ord-700d233806cd4e84a380f38859815a08
Source dataset
uspto-grants-2013_12
Patent number
US08598347B2

Reaction notes

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