HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Hydroxymethyl)benzeneboronic acid → 2-(4-(hydroxymethyl)phenyl)-N-methoxy-N-methylisonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Hydroxymethyl)benzeneboronic acid | HCID 2734706 | — |
| Reactant | 2-Bromo-N-methoxy-N-methylisonicotinamide | HCID 44818654 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | 2-(4-(hydroxymethyl)phenyl)-N-methoxy-N-methylisonicotinamide | HCID 86664344 | — |
Reaction Steps
By following procedures described in Example 32, starting from 2-bromo-N-methoxy-N-methyl-isonicotinamide and 4-hydroxymethyl phenyl boronic acid [but using Pd2(dba)3 instead of Pd(PtBu3)2], step 1 gave 2-(4-hydroxymethyl-phenyl)-N-methoxy-N-methyl-isonicotinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598217B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-e1c29e09dfa24ab88a0d5e9b683c4fda |
| Source note | uspto-grants-2013_12 |