HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate → 4-(2-Cyano-5-methoxycarbonyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate | HCID 56592975 | — |
| Reactant | Methyl 4-cyano-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 56973105 | — |
| Product | 4-(2-Cyano-5-methoxycarbonyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester | HCID 67286487 | — |
Reaction Steps
Using 4-bromo-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester (synthesized based on US 2005/0090529 A1, p82) (1 mol. eq.) and 4-cyano-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester (2.0 mol. eq.) a starting materials, the reaction was performed using General procedure L (Suzuki) to give 4-(2-cyano-5-methoxycarbonyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester. MS(ESI) m/z 378.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598217B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ee6bcc7cc06741f88e4683b870850a2f |
| Source note | uspto-grants-2013_12 |