6-Chloro-3-nitropyridin-2-ylamine → HCID 67285786, compound

HRID 1909045Notes

Reaction equation

HRID 1909045 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.[C:12]([O:16][C:17](=[O:24])[NH:18][CH:19]1[CH2:23][CH2:22][NH:21][CH2:20]1)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17](=[O:24])[NH:18][CH:19]1[CH2:23][CH2:22][N:21]([C:2]2[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[N:7]=2)[CH2:20]1)([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 27240356-Chloro-3-nitropyridin-2-ylamineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamate

Product 1

HCID 67285786HCID 67285786, compound

Procedure

[1-(6-amino-5-nitro-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester was synthesized from 6-chloro-3-nitro-pyridine-2-yl-amine by using the procedure as described in step 1 in Example 160 with the only change being pyrrolidin-3-yl-carbamic acid tert-butyl ester was used as the amine. The intermediate A had following spectral properties.

Sources & evidence

ORD record
ord-e1dd1ff2f25d49429348fd2fb94768f5
Source dataset
uspto-grants-2013_12
Patent number
US08598217B2

Reaction notes

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