Hydrochloric Acid → HCID 66661229, compound

HRID 1909103Notes

Reaction equation

HRID 1909103 reaction equation
[O-:1][N+:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[C:4]([C@H:12]([NH:14]C(=O)OC(C)(C)C)[CH3:13])[CH:3]=1.[ClH:22]>O1CCOCC1>[ClH:22].[O-:1][N+:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[C:4]([C@H:12]([NH2:14])[CH3:13])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86646747HCID 86646747, compound

Product 1

HCID 66661229HCID 66661229, compoundYield 106.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl {(1R)-1-[1-oxido-6-(trifluoromethyl)-3-pyridinyl]ethyl}carbamate (140 mg, 0.457 mmol) in dioxane (2 mL) was added hydrogen chloride (4.0 M in dioxane; 0.343 mL, 1.371 mmol). The reaction mixture was stirred for 4 h. The reaction mixture was concentrated to dryness to give the hydrochloride salt of the title compound (118 mg). MS 207.1 (M+1).

Workup

  1. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-970a3bae15a447f99e0feba7e2310490
Source dataset
uspto-grants-2013_12
Patent number
US08598209B2

Reaction notes

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