Hydrochloric Acid → HCID 25242197, compound

HRID 1909110Notes

Reaction equation

HRID 1909110 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[N:6][CH:7]=1.Cl>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH2:10])[CH3:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66661070HCID 66661070, compound

Product 1

HCID 25242197HCID 25242197, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(1R)-1-(5-fluoropyridin-2-yl)ethyl]-2-methylpropane-2-sulfinamide (34.3 g, 140 mmol) in methyl alcohol (700 mL) at 0° C. was added hydrogen chloride (4.0 M in dioxane; 105 mL, 421 mmol). After 30 min, the mixture was concentrated to dryness. The residue was recrytalized using ethyl alcohol (15 mL) and ether (40 mL). The white solid was filtered and dried under reduced pressure to give the hydrochloride salt of the title compound. MS 141.1 (M+1).

Workup

  1. concentrationthe mixture was concentrated to dryness
  2. filtrationThe white solid was filtered
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-ef2742188eca4b75816e60714c115fb2
Source dataset
uspto-grants-2013_12
Patent number
US08598209B2

Reaction notes

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