4-Chlorobenzoic Acid → HCID 178523612, compound

HRID 1909393Notes

Reaction equation

HRID 1909393 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[Cl:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:31](=[O:32])[C:30]5[CH:34]=[CH:35][C:27]([Cl:26])=[CH:28][CH:29]=5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 63184-Chlorobenzoic AcidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523612HCID 178523612, compound

Procedure

The title compound, white solid (22 mg, 74.9%), MS (ISP) m/z=469.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (24 mg, 0.0595 mmol) and 4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-082a042c3f804ca693c5999cd19eac97
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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