1-(Trifluoromethyl)cyclopropane-1-carboxylic acid → HCID 178523621, compound

HRID 1909405Notes

Reaction equation

HRID 1909405 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[F:26][C:27]([F:35])([F:34])[C:28]1([C:31](O)=[O:32])[CH2:30][CH2:29]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:31]([C:28]5([C:27]([F:35])([F:34])[F:26])[CH2:30][CH2:29]5)=[O:32])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 27783061-(Trifluoromethyl)cyclopropane-1-carboxylic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523621HCID 178523621, compound

Procedure

The title compound, white solid (10 mg, 31.5%), MS (ISP) m/z=467.2 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (25 mg, 0.0681 mmol) and 1-(trifluoromethyl)cyclopropanecarboxylic acid.

Sources & evidence

ORD record
ord-f86443ff73744f83a654a548b9f48f50
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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