1-methyl-1H-imidazole-4-sulfonyl chloride → HCID 178481301, compound

HRID 1909426Notes

Reaction equation

HRID 1909426 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[CH3:26][N:27]1[CH:31]=[C:30]([S:32](Cl)(=[O:34])=[O:33])[N:29]=[CH:28]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][S:32]([C:30]5[N:29]=[CH:28][N:27]([CH3:26])[CH:31]=5)(=[O:34])=[O:33])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178481301HCID 178481301, compound

Procedure

The title compound, white solid (19.5 mg, 45.3%), MS (ISP) m/z=475.1 [(M+H)+], was prepared in accordance with the general method of example 69 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine (intermediate A) (30 mg, 90.8 mmol) and 1-methyl-1H-imidazole-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-5210cc6d4a574d6cb5ff0a14512b0f26
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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